LDN-212320

SKU: orb1308133

Description

LDN-212320

Research Area

Metabolism Research

Key Properties

• CAS Number: 894002-50-7
• MW: 293.39
• Purity: 98.18%
• Formula: C₁₇H₁₅N₃S
• SMILES: Cc1ccccc1CSc1ccc(nn1)-c1ccccn1
• Target: transporter
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.82 mM);DMSO:16.67 mg/mL (56.82 mM)

Bioactivity

• In Vivo:
  After LDN/OSU-0212320(a Single i.p.; 40 mg/kg) treatment, EAAT2 protein levels and associated glutamate uptake increased by approximately 1.5- to 2-fold at 2 hours and by approximately 2- to 3-fold between 8 and 24 hours after injection. Even 72 hours after injection, an approximately 1.5-fold increase in EAAT2 protein levels could still be detected (data not shown). LDN/OSU-0212320–induced EAAT2 protein levels and glutamate uptake was dose-dependent.
• In Vitro:
  LDN/OSU-0212320 enhanced EAAT2 protein levels and glutamate uptake function but did not affect EAAT1 or EAAT3 protein levels and it also increased EAAT2 protein levels in a dose-dependent (EC50: 1.83 ± 0.27 μM) and time-dependent manner. LDN/OSU-0212320 treatment markedly prevented neuronal loss and degeneration, as assessed by MAP2 immunostaining.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

EAAT2, OSU 0212320, OSU0212320, OSU-0212320, Excitatory amino acid transporter 2, Glutamate transporter 1, GLT-1, LDN 212320, LDN212320, LDN-212320, LDN 0212320, LDN0212320, LDN-0212320, LDN/OSU 0212320, LDN/OSU0212320, LDN/OSU-0212320

Compound Identifiers

PubChem CID

7207425