LDHA/PDKs-IN-2

SKU: orb1689041

Description

LDHA/PDKs-IN-2 (compound 20k) is a dual inhibitor of lactate dehydrogenase A (LDHA) and pyruvate dehydrogenase kinases (PDKs), exhibiting IC50 values of 0.7 μM and 1.6 μM, respectively. It shifts cellular metabolism from glycolysis to oxidative phosphorylation, evidenced by increased oxygen consumption and decreased lactate production. This compound demonstrates anti-proliferative activity in cancer research, such as in A549 cells with an EC50 of 15.7 μM.

Research Area

Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 2490699-44-8
• MW: 332.35
• Formula: C₁₇H₂₀N₂O₅
• SMILES: C(=O)(N1CCN(CCOC=2C(=O)C=COC2C)CC1)C3=CC=CO3
• Target: PDK,Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

162657390