LDHA-IN-3

SKU: orb1691042

Description

LDHA-IN-3 is a potent, non-competitive inhibitor of lactate dehydrogenase A (LDHA) with an IC50 of 145.2 nM. This selenobenzene compound is used in cancer research to study metabolic reprogramming in both in vitro and in vivo experimental models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 227010-33-5
• MW: 301.17
• Purity: 99.71% (May vary between batches)
• Formula: C₁₃H₉F₃Se
• SMILES: [Se](C1=CC=C(C(F)(F)F)C=C1)C2=CC=CC=C2
• Target: Dehydrogenase
• Solubility: DMSO:60 mg/mL (199.22 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.64 mM)

Bioactivity

• Target IC50:
  LDHA:145.2 nM (IC50)
• In Vitro:
  LDHA-IN-3 (PSTMB) (0~500 μM; 48 h; MCF-7 cells) has cytotoxic effects. PSTMB (0.01~1 μM) has a dose-dependent inhibitory effect on LDHA activity. PSTMB (0~0.5 μM) inhibits LDHA activity in Michaelis-Menten and Lineweaver-Burk plots. PSTMB (30 and 50 μM; HT29 cells) induces ROS production and mitochondrial damage. PSTMB efficiently binds to LDHA protein. PSTMB induces intrinsic pathway-mediated apoptosis in cancer cells through the production of mitochondrial ROS.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LDHA, LDHA IN 3, LDHAIN3, LDHA-IN-3, 1-(phenylseleno)-4-(trifluoromethyl) benzene, PSTMB

Compound Identifiers

PubChem CID

10494496