LDH-IN-1

SKU: orb1309491

Description

LDH-IN-1 is a potent, pyrazole-derived inhibitor of human lactate dehydrogenase isoforms LDHA and LDHB, exhibiting IC50 values of 32 nM and 27 nM, respectively. This compound is a valuable research tool for investigating cancer metabolism, particularly in in vitro studies targeting glycolysis-dependent tumor cell proliferation.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1964515-43-2
• MW: 570.68
• Purity: 99.84% (May vary between batches)
• Formula: C₃₀H₂₆N₄O₄S₂
• SMILES: NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2cccc(c2)-c2ccccc2)-c2nc(cs2)C(O)=O)cc1
• Target: Dehydrogenase
• Solubility: DMSO:50 mg/mL (87.61 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.5 mM)

Bioactivity

• Target IC50:
  LDHB:27 nM (IC50)|LDHA:32 nM (IC50)
• In Vivo:
  LDH-IN-1 exhibits clearance rates significantly surpassing those of hepatic blood flow in mice (90 mL/min/kg), demonstrating an in vivo clearance of 227 mL/min/kg.
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• In Vitro:
  LDH-IN-1 exhibit low nM inhibition of both LDHA and LDHB, submicromolar inhibition of lactate production, and inhibition of glycolysis in MiaPaCa2 pancreatic cancer and A673 sarcoma cells.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, Lactate Dehydrogenase, LDH IN 1, LDH, LDHA, LDHB, LDHIN1, LDH-IN-1

Compound Identifiers

PubChem CID

131955127