LDC1267

SKU: orb1305722

Description

LDC1267

Research Area

Signal Transduction

Key Properties

• CAS Number: 1361030-48-9
• MW: 560.55
• Purity: 100.00%
• Formula: C₃₀H₂₆F₂N₄O₅
• SMILES: CCOc1cn(nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1)-c1ccc(F)cc1C
• Target: TAM Receptor
• Solubility: Ethanol:2 mg/mL (3.57 mM);DMSO:93 mg/mL (165.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.89 mM)

Bioactivity

• Target IC50:
  Tyro3:8 nM|Axl:29 nM|Mer:<5 nM
• In Vivo:
  In various cell lines, LDC1267 exhibits inhibition of cellular proliferation with an IC50 >5 μM. Moreover, in NKG2D-activated NK cells, LDC1267 can block the inhibitory effect induced by Gas6 stimulation.
• In Vitro:
  In mice bearing B16F10 melanoma, intraperitoneal injection of LDC1267 (20 mg/kg) exhibits high safety and is capable of inhibiting tumor metabolism and enhancing the activity of anti-metastatic NK cells.
• Cell Research:
  After incubation for 72 hours with LDC1267, CellTiterGlow reagent is used to determine the proliferation relative to the corresponding DMSO control.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AXL, Axl, LDC 1267, LDC1267, LDC-1267, Mer, Inhibitor, inhibit, TAMReceptor, TAM Receptor, Tyro3

Compound Identifiers

PubChem CID

56847486