LDC000067

SKU: orb1300656

Description

LDC000067 is a potent and selective CDK9 inhibitor with an IC50 of 44±10 nM. It is a valuable research tool for studying transcriptional regulation in oncology and virology, applicable in both in vitro biochemical assays and cellular mechanism-of-action studies.

Research Area

Cell Biology

Key Properties

• CAS Number: 1073485-20-7
• MW: 370.43
• Purity: 99.07%
• Formula: C₁₈H₁₈N₄O₃S
• SMILES: COc1ccccc1-c1cc(Nc2cccc(CS(N)(=O)=O)c2)ncn1
• Target: CDK,Apoptosis
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:69 mg/mL (186.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.4 mM)

Bioactivity

• Target IC50:
  ABL2/ARG:3640 nM|CDK9:44±10 nM|CDK1-CyclinB1:5513 nM|HGK/MAP4K4:820 nM|CDK4-CyclinD1:9242 nM|CDK2-CyclinA:2441 nM|GSK-3α:1460 nM
• In Vitro:
  LDC000067 reduces Ser2-P, induces p53 activation and leads to apoptosis in mESCs. In addition, LDC067 also dose-dependently inhibits P-TEFb-dependent de novo RNA synthesis of cellular genes.

Storage & Handling

• Storage: store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LDC 000067, LDC 067, LDC000067, LDC-000067, LDC067, LDC-067, Inhibitor, inhibit, Cyclin dependent kinase, CDK9, CDK6, CDK, CDK1, CDK2, CDK4, Apoptosis

Compound Identifiers

PubChem CID

25104564