LD4172

SKU: orb2945672

Description

LD4172 is a potent VHL-based PROTAC that induces RIPK1 degradation with nanomolar DC50. It promotes TNF-α-induced apoptosis in B16F10 cells in vitro and exhibits antitumor efficacy in mouse models, supporting its use in studying necroptosis and oncology research.

Research Area

Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2782022-40-4
• MW: 1149.37
• Formula: C₆₁H₇₅F₃N₁₀O₇S
• SMILES: NC1=C2C(=CN(CCCNC(CCCCCCCCCCC(N[C@H](C(=O)N3[C@H](C(N[C@@H](C)C4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=O)C2=NC=N1)C=6C=C7C(=CC6)N(C(CC8=CC(OC(F)(F)F)=CC=C8)=O)CC7
• Target: PROTACs,RIP kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171430294