LCZ960

SKU: orb3136439

Description

LCZ960 is an orally active glucokinase (GK) activator that stimulates GK activity in liver cells in vitro and enhances glucose uptake in vivo by activating hepatic GK. It effectively lowers blood glucose levels in diet-induced obesity (DIO) in mice. LCZ960 maintains normal blood sugar and improves glucose tolerance in DIO mice and rats. Additionally, LCZ960 stimulates glycogen synthase flux and increases glycogen turnover in the liver of rats, inducing an increase in hepatic glycogen cycling. This compound is useful for research on obesity and type 2 diabetes induced by high-fat diets.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1067877-83-1
• MW: 590.76
• Formula: C₃₀H₃₄N₆O₃S₂
• SMILES: N(C([C@H](CC1CCCC1)C2=CC=C(S(=O)(=O)N3CCN(C)CC3)C=C2)=O)C=4SC=5C(N4)=CC=C(N5)C=6C=CN=CC6
• Target: Glucokinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Glucokinase