LCI133

SKU: orb3174264

Description

LCI133 is an innovative, highly potent, and selective multi-target kinase inhibitor effective at the nanomolar level. It targets CDK4/6/9 and AURKA/B with IC50 values of 4.7/10.2/4.1 nM and 2.8/10.6 nM, respectively. In MYCN-amplified neuroblastoma BE(2)-C cells, LCI133 induces S/G2 phase arrest and triggers significant apoptosis (apoptosis). Moreover, LCI133 demonstrates substantial antitumor efficacy in BE(2)-C neuroblastoma xenograft models.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 3065284-87-6
• MW: 578.67
• Formula: C₃₃H₃₄N₆O₄
• SMILES: O=C1C=C(OC2=CC(=CC=C12)C=3C=CC(=CC3)NC=4N=CC=5C=C(C(=O)N(C)C)N(C5N4)C6CCCC6)N7CCOCC7
• Target: Aurora Kinase,CDK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Aurora Kinase,CDK