LCH-7749944

SKU: orb1309493

Description

LCH-7749944 (GNF-PF-2356) is a potent PAK4 inhibitor (IC50 = 14.93 µM) that suppresses human gastric cancer cell proliferation by targeting the PAK4/c-Src/EGFR/cyclin D1 pathway and induces apoptosis. This small molecule is a useful research tool for studying oncogenic signaling and cell cycle mechanisms in vitro.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 796888-12-5
• MW: 350.41
• Purity: 99.48% (May vary between batches)
• Formula: C₂₀H₂₂N₄O₂
• SMILES: COc1cccc(Nc2nc(NCC3CCCO3)c3ccccc3n2)c1
• Target: Apoptosis,PAK
• Solubility: DMSO:250 mg/mL (713.45 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.27 mM)

Bioactivity

• Target IC50:
  PAK4:14.93 μM
• In Vitro:
  LCH-7749944 (5-20 μM; 12-48 hours) prominently induces a dose-dependent increase in the percentage of cells in G1 phase and decrease in S phase. LCH-7749944 (5-30 μM; 24 hours) dramatically decreases levels of phosphoPAK4, phospho-c-Src, phospho-EGFR and cyclin D1 protein expression in a dose-dependent manner. LCH-7749944 (GNF-PF-2356; 5-50 μM; 24 hours) inhibits the proliferation of MKN-1, BGC823, SGC7901 and MGC803 cells in a concentration dependent manner. LCH-7749944 (5-20 μM; 12-48 hours) induces apoptosis of SGC7901 cells.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Apoptosis, apoptosis, cancer, c-Src, cyclin, cells, EGFR, human, GNF-PF 2356, GNF-PF2356, GNF-PF-2356, Inhibitor, gastric, LCH 7749944, LCH7749944, LCH-7749944, inhibit, PAK4, PAK, p21 activated kinases, proliferation

Compound Identifiers

PubChem CID

2951910