LCB-2151

SKU: orb3173070

Description

LCB-2151 (Compound 2) is a nucleoside analog and an anticancer agent. It disrupts the two main sources of ATP production, glycolysis and mitochondrial oxidative phosphorylation, reducing the bioenergetic capacity of KRAS mutant pancreatic cancer cells and inducing the formation of ROS. LCB-2151 effectively inhibits key enzymes in glycolysis, the TCA cycle, and fatty acid β-oxidation, such as CACT and CPT2. It demonstrates significant cytotoxicity and can induce apoptosis. LCB-2151 is applicable in cancer radiotherapy research.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2211175-99-2
• MW: 825.87
• Formula: C₃₇H₄₃F₈N₃O₅S₂
• SMILES: FC1(F)[C@@H](O[C@H](CO)[C@]1(CO)C)N2C(=O)N=C(NC(CC(CC[C@@H](SCC3=CC=C(C(F)(F)F)C=C3)CCSCC4=CC=C(C(F)(F)F)C=C4)(C)C)=O)C=C2
• Target: Mitochondrial Metabolism,ROS,Apoptosis,OXPHOS

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Mitochondrial Metabolism,ROS,Apoptosis,OXPHOS