LCB-2122

SKU: orb3174691

Description

LCB-2122 is an adenosine-like nucleoside analog featuring a C2'-stereoisomeric all-carbon quaternary carbon center. It inhibits doxorubicin-induced myocardial apoptosis with an IC50 value of 0.5 μM and also suppresses imatinib-induced apoptosis. LCB-2122 activates the AMPK signaling pathway, inducing the phosphorylation of AMPK and its downstream substrate acetyl-CoA carboxylase (ACC). Additionally, LCB-2122 alleviates mitochondrial damage caused by doxorubicin and is used in heart failure research.

Key Properties

• CAS Number: 2210298-14-7
• MW: 465.83
• Formula: C₁₆H₂₅ClN₅O₇P
• SMILES: C(O)[C@@]1(C)[C@@H](O[C@H](COP(OCC)(OCC)=O)[C@H]1O)N2C=3C(N=C2)=C(N)N=C(Cl)N3
• Target: Nucleoside Antimetabolite/Analog,AMPK,Acetyl-CoA Carboxylase,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Nucleoside Antimetabolite/Analog,AMPK,Acetyl-CoA Carboxylase,Apoptosis