LCB 03-0110

SKU: orb1297957

Description

LCB 03-0110 is a potent small molecule inhibitor targeting discoidin domain receptors (DDRs) and multiple key tyrosine kinases such as c-Src, SYK, BTK, and VEGFR2. Its activity against these signaling pathways makes it a useful research tool for in vitro studies of inflammation, angiogenesis, and immune cell function.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1228102-01-9
• MW: 417.52
• Purity: 99.12% (May vary between batches)
• Formula: C₂₄H₂₃N₃O₂S
• SMILES: N(C1=C2C(C=C(S2)C3=CC(CN4CCOCC4)=CC=C3)=NC=C1)C5=CC(O)=CC=C5
• Target: Discoidin Domain Receptor (DDR),Src
• Solubility: DMSO:45 mg/mL (107.78 mM)

Bioactivity

• In Vivo:
  LCB 03-0110 applied topically to full excisional wounds on rabbit ears suppressed the accumulation of myofibroblast and macrophage cells in the healing wound and reduced hypertrophic scar formation after wound closing, without delaying the wound closing process.
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• In Vitro:
  In J774A.1 macrophage cells activated by lipopolysaccharide LCB 03-0110 inhibited cell migration and nitric oxide, inducible nitric-oxide synthase, cyclooxygenase 2, and tumor necrosis factor-α synthesis.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LCB 03 0110, LCB 030110, LCB 03-0110, DDR, DiscoidinDomainReceptor(DDR), Discoidin Domain Receptor, Discoidin Domain Receptor (DDR), DiscoidinDomainReceptor, 3-(2-(3-(Morpholinomethyl)phenyl)thieno[3,2-b]pyridin-7-ylamino)phenol

Compound Identifiers

PubChem CID

71577234