LC-SF-14

SKU: orb3027968

Description

LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR, with IC50 values of 71.6 nM and 8.9 nM, respectively. It blocks FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation, and also inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). Furthermore, LC-SF-14 exhibits antitumor activity in SNU-16 xenograft mouse models, making it suitable for research on FGFR2-driven gastric cancer.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Key Properties

• Formula: C₄₄H₅₀Cl₃N₁₃O₅S
• Target: p38 MAPK,Phosphatase,FGFR,ERK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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Gene Symbol

p38 MAPK,Phosphatase,FGFR,ERK