Lazertinib mesylate

SKU: orb3027911

Description

Lazertinib (mesylate) (YH25448 (mesylate); GNS-1480 (mesylate)) is an orally active EGFR inhibitor capable of crossing the blood-brain barrier. It suppresses the p-EGFR, p-AKT, and p-ERK signaling pathways, leading to apoptosis. Lazertinib (mesylate) demonstrates antitumor activity in the H1975-luc BM xenograft model in mice and is applicable for researching non-small cell lung cancer.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2247995-37-3
• MW: 650.75
• Formula: C₃₁H₃₈N₈O₆S
• SMILES: O=C(C=C)NC1=CC(NC2=NC=CC(=N2)N3N=C(C=4C=CC=CC4)C(=C3)CN(C)C)=C(OC)C=C1N5CCOCC5.O=S(=O)(O)C
• Target: EGFR,ERK,Akt

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

EGFR,ERK,Akt