Lats-IN-1

SKU: orb1298408

Description

Lats-IN-1 is a potent, ATP-competitive inhibitor of the kinases Lats1 and Lats2. By inhibiting these kinases, it activates Yap signaling and has been shown to stimulate proliferation in postmitotic mammalian tissues in research settings, making it a valuable tool for studying the Hippo pathway in vitro and in vivo.

Research Area

Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1424635-83-5
• MW: 334.39
• Purity: 99.82% (May vary between batches)
• Formula: C₁₈H₁₄N₄OS
• SMILES: O=C(\N=c1/sccn1Cc1ccccc1)c1c[nH]c2ncccc12
• Target: YAP
• Solubility: DMSO:83.33 mg/mL (249.2 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (9.87 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

YAP, Yes-associated protein, inhibit, Inhibitor, Lats IN 1, Lats1, Lats2, LatsIN1, Lats-IN-1

Compound Identifiers

PubChem CID

71890885