Latrepirdine dihydrochloride

SKU: orb1685652

Description

Latrepirdine dihydrochloride

Research Area

Cell Biology, Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 97657-92-6
• MW: 392.37
• Purity: 98.45%
• Formula: C₂₁H₂₅N₃·2HCl
• SMILES: Cl.Cl.CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccc(C)nc1
• Target: Autophagy,Beta Amyloid,Adrenergic Receptor,GluR,Histamine Receptor,5-HT Receptor
• Solubility: DMSO:39.2 mg/mL (99.91 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.27 mM)

Bioactivity

• In Vivo:
  Latrepirdine treatment of TgCRND8 transgenic mice is linked to improved learning behavior and reduced accumulation of Aβ42 and α-synuclein. Latrepirdine administration results in increased levels of biomarkers associated with autophagy activation in the brains of TgCRND8 (APP K670M, N671L, V717F) or wild-type mice, and is also associated with behavioral improvement, reduced Aβ neuropathology, and prevention of autophagic failure in TgCRND8 mice.
• In Vitro:
  Latrepirdine increases succinate dehydrogenase activity (MTT-assay), mitochondrial membrane potential (DeltaPsim), and cellular ATP levels in primary mouse cortical neurons and human neuroblastoma cells (SH-SY5Y). Latrepirdine enhances mitochondrial function both in the absence and presence of stress and Dimebon-treated cells are partially protected to maintain cell viability. Latrepirdine leads to enhanced mTOR- and Atg5-dependent autophagy in cultured mammalian cells. latrepirdine stimulates MTOR- and ATG5-dependent autophagy, leading to the reduction of intracellular levels of APP metabolites, including Aβ in cultured cells. Latrepirdine stimulates the degradation of α-syn in differentiated SH-SY5Y neurons, and in mouse brain following chronic administration, in parallel with elevation of the levels of markers of autophagic activity. Latrepirdine increases intracellular ATP levels and glucose transporter 3 translocation to the plasma membrane in primary neuron.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta Amyloid, BetaAmyloid, Dimebolin dihydrochloride, bAmyloid, Amyloid-β, Autophagy, b Amyloid, 5-HT Receptor, Adrenergic Receptor, AdrenergicReceptor, 5HT Receptor, 5HTReceptor, GluR, Histamine Receptor, HistamineReceptor, Latrepirdine 2HCl, β Amyloid, βAmyloid

Compound Identifiers

PubChem CID

23729232