Lasofoxifene Tartrate

SKU: orb1299459

Description

Lasofoxifene Tartrate (CP-336156) is a non-steroidal, third-generation selective estrogen receptor modulator (SERM). It is utilized in research for studying osteoporosis and breast cancer, with applications in both in vitro receptor binding assays and in vivo models for evaluating bone density and mammary tumorigenesis.

Research Area

Metabolism Research

Key Properties

• CAS Number: 190791-29-8
• MW: 563.64
• Purity: 98.96% (May vary between batches)
• Formula: C₃₂H₃₇NO₈
• SMILES: O[C@@H]([C@H](O)C(O)=O)C(O)=O.Oc1ccc2[C@H]([C@H](CCc2c1)c1ccccc1)c1ccc(OCCN2CCCC2)cc1
• Target: Estrogen Receptor/ERR
• Solubility: DMSO:6 mg/mL (10.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.77 mM)

Bioactivity

• In Vivo:
  Lasofoxifene (LAS) and BZA reduced the clinical severity of arthritis as well as the grade of histologic synovitis and erosions on cartilage and bone. Moreover, SERMs protected against generalised bone loss in CIA by increasing trabecular BMD. Both SERMs decreased serum marker of cartilage destruction and LAS reduced serum IL-6 levels. SERMs did not alter Th17 cells in lymph nodes as E2 did.
• Animal Research:
  Female DBA/1 mice were ovariectomised and subjected to CIA as a model of post-menopausal RA. Mice received treatment with Lasofoxifene (LAS), BZA, 17β-estradiol (E2) as reference or vehicle. Arthritis development was assessed and BMD was determined by peripheral quantitative CT of the femurs. Serologic markers of inflammation and cartilage destruction were analysed. Immune cells in lymph nodes were studied by flow cytometry.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

arthritis, breast cancer, CP 336156, CP336156, CP-336156, Inhibitor, Lasofoxifene, Lasofoxifene Tartrate, EstrogenReceptor, Estrogen Receptor/ERR, Estrogen Receptor, ERR, endocrine resistant, inhibit, oestrogen, oestrogen receptor, osteoporosis, selective oestrogen receptor modulators, tartrate

Compound Identifiers

PubChem CID

3081919