Laromustine

SKU: orb1739251

Description

Laromustine (VNP40101M) is a sulfonylhydrazine prodrug with alkylating activity, developed for cancer research. It demonstrates significant anticancer effects in studies of acute myeloid leukemia, where it functions as a thioredoxin reductase inhibitor in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 173424-77-6
• MW: 307.78
• Purity: ≥98% (May vary between batches)
• Formula: C₆H₁₄ClN₃O₅S₂
• SMILES: O=C(NC)N(N(CCCl)S(=O)(=O)C)S(=O)(=O)C
• Target: DNA/RNA Synthesis

Bioactivity

• Target IC50:
  CYP2B6:125 mM (Ki)|CYP2C19:349 mM (ki)|CYP3A4/5:297 mM (Ki)
• In Vitro:
  Laromustine caused direct inhibition of CYP2B6 and CYP3A4/5 as well as of CYP2C19. CYP2B6 K(i)=125 mM, CYP3A4/5 K(i)=297 mM, and CYP2C19 K(i)=349 mM and were greater than the average clinical plasma C(max) of Laromustine (C(max)=25 mM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VNP 40101M, VNP40101M, RNASynthesis, RNA Synthesis, DNASynthesis, DNA Synthesis, DNA/RNA Synthesis

Compound Identifiers

PubChem CID

3081349