Lappaconitine hydrobromide

SKU: orb1300658

Description

Allapinine (Lappaconitine hydrobromide) is a diterpenoid alkaloid derived from Aconitum sinomontanum Nakai, recognized for its anti-inflammatory properties. It serves as a research tool for investigating sodium channel modulation in models of arrhythmia and neuropathic pain, with applications in both in vitro and in vivo pharmacological studies.

Key Properties

• CAS Number: 97792-45-5
• MW: 665.61
• Purity: 99.76% (May vary between batches)
• Formula: C₃₂H₄₄N₂O₈·HBr
• SMILES: Br.[H][C@]12C[C@]3([H])[C@](O)([C@H]1OC)[C@](O)(C[C@@H]2OC)[C@H]1C[C@@]2([H])[C@]33C1N(CC)C[C@@]2(CC[C@@H]3OC)OC(=O)c1ccccc1NC(C)=O
• Target: Others
• Solubility: DMSO:28 mg/mL (42.07 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  LD50: Mice 10.5 mg/kg (i.p.); Rats 9.9 mg/kg (i.p.)
• In Vitro:
  Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg/L to 40 mg/L, the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Allapinine, Lappaconite HBr, Lappaconitine hydrobromide, Lappaconitine Hydrobromide

Compound Identifiers

PubChem CID

51346120