Lapatinib ditosylate monohydrate

SKU: orb1310961

Description

Lapatinib ditosylate monohydrate is a tyrosine kinase inhibitor used to treat advanced breast cancer and other solid tumors. It is widely employed in both in vitro and in vivo cancer research to study EGFR and HER2 signaling pathways. Its use is associated with transient aminotransferase elevations and rare cases of acute liver injury.

Research Area

Cardiovascular Research, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 388082-78-8
• MW: 943.47
• Purity: >99.99% (May vary between batches)
• Formula: C₂₉H₂₆ClFN₄O₄S·2(C₇H₈O₃S)·H₂O
• SMILES: n1cnc(c2cc(ccc12)c1oc(cc1)CNCCS(=O)(=O)C)Nc1cc(c(cc1)OCc1cc(ccc1)F)Cl.c1(ccc(cc1)C)S(=O)(=O)O.O.c1(ccc(cc1)C)S(=O)(=O)O
• Target: EGFR,Autophagy,Ferroptosis
• Solubility: DMSO:91 mg/mL (96.45 mM)

Bioactivity

• Target IC50:
  EGFR:10.8 nM|ERB4:367 nM|ErbB2:9.2 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lapatinib ditoluenesulfonate, Lapatinib ditoluenesulfonate monohydrate, Lapatinib ditosilate hydrate, Lapatinib ditosylate monohydrate, HER2/ErbB2, EGFR, Ferroptosis, GW2016 ditosylate, GW572016 ditosylate, Autophagy, Tyverb, Tyverb ditosylate monohydrate, Tykerb, Tykerb ditosylate monohydrate

Compound Identifiers

PubChem CID

11557040