Lapachol

SKU: orb1221729

Description

Lapachol has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is inhibitor of epithelial tumors in Drosophila melanogaster heterozygote.

Key Properties

• CAS Number: 84-79-7
• MW: 242.27
• Purity: >98% (HPLC)
• Formula: C₁₅H₁₄O₃
• SMILES: CC(C)=CCC1=C(O)C(=O)c2ccccc2C1=O
• Target: others
• Solubility: In Vitro: DMSO : 66.67 mg/mL (275.19 mM)

Bioactivity

• In Vivo:
  Animal model: Male DBA1/J mice (10-12 weeks old) with collagen-induced arthritis (CIA) models. Dosage: 3 mg/kg and 10 mg/kg. Administration: Orally; once a day for 4 weeks. Result: Markedly attenuated the severity of arthritis in CIA mice at both doses. Markedly reduced all histopathological features of arthritis severity.
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• In Vitro:
  Cell Proliferation Assay Cell line: Murine CD4 T cells. Concentration: 10, 30, 100 μM. Incubation time: 4 days. Result: Inhibited the proliferation of murine CD4 T cells in a dose-dependent manner.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Lapachol | NSC-11905 | Tecomin | Bethabarra wood

Quick Database Links

Gene Symbol

others