Lansoprazole

SKU: orb1310397

Description

Lansoprazole is a timoprazole-derived proton pump inhibitor used to treat gastric ulcers and Zollinger-Ellison syndrome by inhibiting H+/K+-ATPase in parietal cells. It also acts as a brain-penetrant neutral sphingomyelinase (N-SMase) inhibitor, making it a useful tool for studying exosome biology and neuroinflammation in both in vitro and in vivo research models.

Research Area

Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 103577-45-3
• MW: 369.36
• Purity: 99.84% (May vary between batches)
• Formula: C₁₆H₁₄F₃N₃O₂S
• SMILES: CC1=C(CS(=O)C2=NC3=CC=CC=C3N2)N=CC=C1OCC(F)(F)F
• Target: Phospholipase,Proton pump,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.41 mM);DMSO:50 mg/mL (135.37 mM)

Bioactivity

• In Vivo:
  Lansoprazole is a potent antisecretory agent that inhibits gastric acid secretion by blocking the stomach's hydrogen/potassium adenosine triphosphatase (H+, K+-ATPase). It suppresses the upregulation of adhesion molecules in blood vessels, neutrophil activation, and the production of pro-inflammatory cytokines from activated endothelial cells. Furthermore, Lansoprazole induces the expression of various genes in gastric epithelial cells, including Phase II detoxifying enzymes (NADPH-quinone oxidoreductase, glutathione S-transferase) and antioxidative stress proteins (HO-1, thioredoxin reductase, and superoxide dismutase). In rat gastric epithelial cells, Lansoprazole upregulates HO-1 expression and exerts anti-inflammatory effects.
• In Vitro:
  Lansoprazole significantly attenuates intestinal damage induced by ischemia-reperfusion or indomethacin. Exogenous administration of Lansoprazole can prevent injury to the small intestine caused by ischemia-reperfusion or indomethacin. Lansoprazole inhibits acute inflammatory responses and mucosal injury in rats subjected to ischemia-reperfusion or indomethacin-induced damage.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, A 65006, acid, A65006, A-65006, AG 1749, AG1749, AG-1749, N-SMase, inhibit, ELT, exosome, Inhibitor, gastric, HFD, Lansoprazole, TSTQ, Proton Pump, Proton pump, Protonpump, STZ, Phospholipase

Compound Identifiers

PubChem CID

3883