(R)-Lansoprazole

SKU: orb1310031

Description

(R)-Lansoprazole is the R-enantiomer of the proton pump inhibitor lansoprazole. It also acts as a brain-penetrant inhibitor of neutral sphingomyelinase (N-SMase), enabling research into exosome biology and neuroinflammation in both cellular and animal models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 138530-94-6
• MW: 369.36
• Purity: 98.99% (May vary between batches)
• Formula: C₁₆H₁₄F₃N₃O₂S
• SMILES: Cc1c(OCC(F)(F)F)ccnc1CS(=O)c1nc2ccccc2[nH]1
• Target: Proton pump
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (148.91 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.41 mM)

Bioactivity

• In Vitro:
  Dexlansoprazole, constitutes >80% of circulating drug after oral administration of lansoprazole, provides lower clearance and 5-fold greater systemic exposure than the S-enantiomer following oral administration of lansoprazole. Dexlansoprazole MR is a modified release formulation of dexlansoprazole, which employs a novel Dual Delayed Release (DDR) technology that delivers the drug in two discrete phases of release, thereby inhibiting newly activated proton pumps that turn over following initial PPI inactivation of H+,K+-ATPase. Dexlansoprazole MR maintains plasma drug concentrations above the threshold level longer than lansoprazole at all doses, resulting in an optimized drug exposure-intragastric pH relationship. Dexlansoprazole selectively suppresses gastric acid secretion by direct inhibition of the H+K+-ATPase proton pump in the gastric parietal cell, inhibition of this cell membrane enzyme ultimately blocks the final step in acid production.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

R-(+)-Lansoprazole, R-Lansoprazole, Proton Pump, Proton pump, Protonpump, T 168390, T168390, T-168390, TAK 390, TAK390, TAK-390, Lansoprazole, Inhibitor, inhibit, (R) Lansoprazole, (R)Lansoprazole, (R)-Lansoprazole, Dexlansoprazole

Compound Identifiers

PubChem CID

3883