Laninamivir

SKU: orb1308141

Description

Laninamivir (R 125489) is a potent neuraminidase inhibitor effective against multiple influenza strains, including avian H12N5, pH1N1, and H2N2 N2 subtypes. It is a valuable research tool for studying influenza virus replication and has demonstrated antiviral activity in both in vitro enzymatic assays and in vivo animal infection models.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 203120-17-6
• MW: 346.34
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₂₂N₄O₇
• SMILES: [H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](OC)[C@H](O)CO
• Target: Influenza Virus
• Solubility: H2O:10 mM;DMSO:Insoluble

Bioactivity

• Target IC50:
  N5:0.90 nM (IC50)|p09N1:1.83 nM (IC50)|p57N2:3.12 nM (IC50)
• In Vitro:
  Laninamivir is effective against p57N2, p09N1, and N5 with a similar binding mode to Zanamivir. Laninamivir inhibits efficiently common oseltamivir-resistant viruses, including those with the ubiquitous His274Tyr substitution .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

p57N2, inhibit, InfluenzaVirus, influenza neuraminidase (NA), Influenza Virus, p09N1, N5, Laninamivir, Inhibitor, R 125489, R125489, R-125489

Compound Identifiers

PubChem CID

502272