Lamotrigine

SKU: orb1310392

Description

Lamotrigine

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 84057-84-1
• MW: 256.09
• Purity: 99.95%
• Formula: C₉H₇Cl₂N₅
• SMILES: NC1=NN=C(C(N)=N1)C1=CC=CC(Cl)=C1Cl
• Target: Sodium Channel,5-HT Receptor,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.81 mM);DMSO:43.33 mg/mL (169.2 mM);Ethanol:2.6 mg/mL (10.15 mM)

Bioactivity

• Target IC50:
  5-HT (rat brain synaptosomes):474 μM|5-HT (human platelets):240 μM
• In Vivo:
  In rat cortical brain tissues cultured with 10 mg/L veratridine, Lamotrigine inhibited the release of glutamate and aspartate (both with an ED50 of 5.38 mg/L) twice as effectively as it inhibited the release of GABA (ED50 of 11.2 mg/L), without affecting the basal release of glutamate. Lamotrigine stabilizes presynaptic neuronal membranes by blocking voltage-dependent sodium channels, thereby preventing the release of excitatory neurotransmitters, especially glutamate and aspartate. It does not induce phencyclidine (PCP)-like central nervous system effects, does not act through direct inhibition of NMDA receptors, and may avoid the adverse effects associated with NMDA blockade.
• In Vitro:
  Lamotrigine is active in electrically induced EEG after-discharge tests, indicating its ability to counteract simple and complex partial seizures. It demonstrates antiepileptic effects in mice and rats, preventing hind-limb extension induced by both MES (maximal electroshock) and pentylenetetrazole. The peak effects of Lamotrigine occur 1 hour post-administration, with a duration exceeding 24 hours. Intravenous administration of Lamotrigine at doses greater than 5 mg/kg in rats results in a dose-dependent reduction in after-discharge duration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, BW430C, 5-HT (human platelets), 5-HT (rat brain synaptosomes), 5HTReceptor, 5HT Receptor, inhibit, Na+ channels, Na channels, LTG, Lamotrigine, Lennox-Gastaut syndrome, Inhibitor, focal seizure, epilepsy, tonic-clonic seizure, Sodium Channel, SodiumChannel, seizure

Compound Identifiers

PubChem CID

3878