Lamivudine

SKU: orb1310390

Description

Lamivudine

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 134678-17-4
• MW: 229.26
• Purity: >99.99% (May vary between batches)
• Formula: C₈H₁₁N₃O₃S
• SMILES: O=C1N([C@H]2O[C@@H](CO)SC2)C=CC(N)=N1
• Target: HBV,Reverse Transcriptase,HIV Protease
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (21.81 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:240 mg/mL (1046.85 mM);H2O:42 mg/mL (183.2 mM)

Bioactivity

• In Vivo:
  Lamivudine exhibits selective inhibitory activity against deoxycytidine kinase, an unusual substrate for the non-natural L-isomer of dNTPs preferred by HBV polymerase. The anti-HBV activity of PCV is attributed to the broad substrate specificity of deoxycytidine kinase and an unusual substrate preference of HBV polymerase for the non-natural L-conformation of dNTPs. The anti-HBV efficacy of PCV appears to rely on multiple factors, including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity), the extended intracellular half-life of PCV-TP, and the ability of PCV-TP to inhibit the initiation of HBV RT as well as its RT and DNA polymerase activities. Combined use of Lamivudine and Cidofovir synergistically inhibits replication of duck hepatitis B virus and is more effective in reducing the persistent covalently closed circular (CCC) DNA form of DHBV than when used separately. In PBMCs, Lamivudine inhibits HIV-1 p24 antigen production with ED50s ranging from 0.07 μM to 0.2 μM.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CNS penetration,brain region, BCH 189, BCH189, BCH-189, Hepatitis B virus, Inhibitor, HBV, Lamivudine, HIV neurodegeneration, HIV Protease, HIV, HIVProtease, GR109714X, Human immunodeficiency virus, orally active, inhibit, susceptible, ReverseTranscriptase, Reverse Transcriptase

Compound Identifiers

PubChem CID

60825