Lalistat 1

SKU: orb1692093

Description

Lalistat 1 is a potent inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and H. influenzae IgA1 protease. This small molecule is utilized in biochemical and cellular research, including in vitro studies investigating lipid metabolism disorders such as Niemann-Pick disease type C.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 501104-16-1
• MW: 298.36
• Purity: 99.70% (May vary between batches)
• Formula: C₁₂H₁₈N₄O₃S
• SMILES: O=C(Oc1nsnc1N1CCCCC1)N1CCOCC1
• Target: Antibacterial
• Solubility: DMF:20 mg/mL (67.03 mM);DMSO:45 mg/mL (150.82 mM);Ethanol:20 mg/mL (67.03 mM)

Bioactivity

• Target IC50:
  LAL (human):68 nM (IC50)
• In Vitro:
  Lalistat 1 (0-100 μM) inhibits IgA1P B1 and B2 dose-dependently, achieving near-complete inhibition at 50 μM and complete inhibition at 100 μM . Additionally, Lalistat 1 reduces cholesterol accumulation in lysosome-like reservoirs of GM03123 human fibroblasts lacking NPC1 .
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ZINC795230, ZINC-795230, ZINC 795230, Lalistat 1, Bacterial

Compound Identifiers

PubChem CID

651937