LAB687

SKU: orb3136887

Description

LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.

Research Area

Metabolism Research, Pharmacology & Drug Discovery, Protein Biochemistry, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 256397-11-2
• MW: 468.47
• Formula: C₂₆H₂₃F₃N₂O₃
• SMILES: C(NC=1C=C2C(=CC1)C[C@@H](NC(OC)=O)C2)(=O)C3=C(C(C)=CC=C3)C4=CC=C(C(F)(F)F)C=C4
• Target: Hedgehog/Smoothened,MTP,Smo

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Hedgehog/Smoothened,MTP,Smo