LA-CB1

SKU: orb3028645

Description

LA-CB1 is a derivative of Abemaciclib that targets CDK4/6 and promotes their degradation via the ubiquitin-proteasome pathway, thereby blocking the CDK4/6-Cyclin D1-Rb-E2F axis and inducing G0/G1 cell cycle arrest and apoptosis (Apoptosis). It demonstrates antiproliferative activity against MDA-MB-231 cells with an IC50 of 0.27 µM and effectively inhibits epithelial-mesenchymal transition, cell migration, invasion, and angiogenesis. In highly invasive models like triple-negative breast cancer (TNBC), LA-CB1 significantly suppresses tumor growth, showing robust dose-dependent antitumor activity. This compound can be utilized in breast cancer research.

Research Area

Cell Biology

Key Properties

• CAS Number: 3032908-44-1
• MW: 527.98
• Formula: C₂₈H₂₃ClFN₇O
• SMILES: N#CC1=CC=CN=C1COC2=CC=C(C=C2Cl)NC=3N=CC=C(N3)C=4C=C(F)C=5N=C(N(C5C4)C(C)C)C
• Target: CDK,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Apoptosis