L82

SKU: orb1689277

Description

L82 is a selective, non-competitive inhibitor of human DNA Ligase I (hLig1 IC50=12 µM). It exhibits anti-proliferative effects in breast cancer cell models, making it a useful research tool for studying DNA replication and repair mechanisms in oncology.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 329227-30-7
• MW: 309.67
• Purity: 97.45% (May vary between batches)
• Formula: C₁₁H₈ClN₅O₄
• SMILES: Oc1ccc(\C=N\Nc2cn[nH]c(=O)c2Cl)cc1[N+]([O-])=O
• Target: DNA,DNA/RNA Synthesis
• Solubility: DMSO:6 mg/mL (19.38 mM)

Bioactivity

• Target IC50:
  DNA ligase I:12 μM
• In Vitro:
  L82 (0-50 μM; 6 d) reduced the proliferation of a normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa, and HCT116 in a concentration-dependent manner. L82 (50 μM; 0-48 h) shows cytostatic activity due to activation of the G1/S checkpoint in MCF7 cells.' Revised: L82 (0-50 μM; 6 d) concentration-dependently reduced proliferation in the normal breast epithelial cell line MCF10A and the breast cancer cell lines MCF7, HeLa, and HCT116, while L82 (50 μM; 0-48 h) exhibited cytostatic activity through activation of the G1/S checkpoint in MCF7 cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Ligase I

Compound Identifiers

PubChem CID

135651244