L748337

SKU: orb1704429

Description

L748337 is a potent competitive antagonist of β1-, β2-, and β3-adrenoceptors. It blocks CL316243 effects, activates MAPK/Erk1/2 signaling, and is a valuable research tool for studying β3-adrenoceptor-related disorders in metabolic and cardiovascular research, applicable in both in vitro and in vivo models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 244192-94-7
• MW: 497.61
• Purity: >99.99% (May vary between batches)
• Formula: C₂₆H₃₁N₃O₅S
• SMILES: CC(=O)NCc1cccc(OC[C@@H](O)CNCCc2ccc(NS(=O)(=O)c3ccccc3)cc2)c1
• Target: Adrenergic Receptor
• Solubility: DMSO:80 mg/mL (160.77 mM);Ethanol:20 mg/mL (40.19 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.63 mM)

Bioactivity

• Target IC50:
  β3-adrenoceptor:4 nM (Ki)|β1-adrenoceptor:390 nM (Ki)|β2-adrenoceptor:204 nM (Ki)
• In Vivo:
  L748337 (5 mg/kg) exhibits anti-cancer effects in male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cells.
• In Vitro:
  The β3-adrenergic receptor selective antagonist L748337 (100nM) partially antagonized the relaxation induced by (-)-isoprenaline in cav-1KO arteries, but did not antagonize the relaxation in WT arteries.

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AdrenergicReceptor, Adrenergic Receptor, L 748337, L748337, L-748337, L-748,337, β1-adrenergic receptor, β2-adrenergic receptor, β3-adrenergic receptor

Compound Identifiers

PubChem CID

10028830