L524-0366

SKU: orb1298823

Description

L524-0366 is a small molecule inhibitor that selectively targets the TWEAK-Fn14 signaling pathway. It is used in research to investigate this pathway's role in cancer and inflammatory diseases, with applications in both in vitro and in vivo experimental models.

Research Area

Cell Biology

Key Properties

• CAS Number: 951612-19-4
• MW: 308.8
• Purity: >98%
• Formula: C₁₃H₁₃ClN₄OS
• SMILES: C(=O)(C1=CN(N=N1)C2=CC(Cl)=CC=C2)N3CCSCC3
• Target: Others,TNF
• Solubility: Soluble in DMSO (up to 14 mg/ml with warming) or in Ethanol (up to 2 mg/ml with warming).

Bioactivity

• Target IC50:
  sTWEAK:7.8 µM
• In Vitro:
  L524-0366 mitigated maladaptive remodeling with TAC. TWEAK induced secretion of the pro-inflammatory chemokine, monocyte chemoattractant protein 1 from WT but not Fn14-/- fibroblasts in vitro, in part through activation of non-canonical NF-κB signaling. Finally, Fn14 expression was increased in mouse following TAC and in human failing hearts.
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• Cell Research:
  Wild type (WT) and Fn14 knock out (Fn14-/-) mice were subjected to pressure overload [transaortic constriction (TAC)] for 1 or 6 weeks. A subset of WT TAC animals were treated with the Fn14 antagonist L524-0366. Cardiac function was measured by echocardiography. Cardiac fibrosis and macrophage infiltration were quantified using immunohistochemistry and flow cytometry, respectively. Cardiac fibroblasts were isolated for quantifying TWEAK-induced chemokine release.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

[1-(3-chlorophenyl)triazol-4-yl]-thiomorpholino-methanone, L524 0366, L5240366, L-524-0366, L524-0366, Fn14

Compound Identifiers

PubChem CID

20973801