L-Thyroxine sodium

SKU: orb1305981

Description

L-Thyroxine sodium is the primary synthetic form of the thyroid hormone and acts as an agonist for thyroid hormone receptors alpha and beta. It is widely used in research to study metabolism, development, and gene regulation in both cellular (in vitro) and animal (in vivo) models.

Research Area

Metabolism Research

Key Properties

• CAS Number: 55-03-8
• MW: 798.85
• Purity: 99.56% (May vary between batches)
• Formula: C₁₅H₁₀I₄NO₄.Na
• SMILES: [Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
• Target: Endogenous Metabolite,Thyroid hormone receptor(THR)
• Solubility: DMSO:27.5 mg/mL (34.42 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.5 mM)

Bioactivity

• In Vitro:
  evothyroxine (L-T(4))can upregulate the expression of P-gp mRNA and protein in LS180 cells, but only L-T(4) and L-T(3) can produce the same effect in Caco-2 cells, which are relatively lacking in PXR
• Cell Research:
  Cell lines: LS180V cells. Concentrations: 100 nM and 100μM. Incubation Time: 72 h. Method: LS180V cells are induced for 72 h with two l-T4 concentrations of 100 nM and 100 μM.
• Animal Research:
  Animal Models: SD rats. Dosages: 20 μg/kg/day and 100 μg/kg/day. Administration: i.p.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Levothyroxine, Levothyroxine sodium, inhibit, L Thyroxine sodium, L-Thyroxine, LThyroxine sodium, L-Thyroxine sodium, LT4 sodium, L-T4 sodium, T 4, T-4, Thyroid hormone receptor(THR), Thyroidhormonereceptor, Thyroidhormonereceptor(THR), Thyroid Hormone, Thyroid hormone receptor, Thyroid Hormone Receptor, THR

Compound Identifiers

PubChem CID

23666112