L-NMMA

SKU: orb1308144

Description

L-NMMA acetate (Tilarginine acetate) is a pan-nitric oxide synthase (NOS) inhibitor, exhibiting Ki values of 0.18 µM for nNOS, 0.4 µM for eNOS, and 6 µM for iNOS. It is widely used in cardiovascular and septic shock research to study NO signaling pathways in both cellular and animal models.

Research Area

Cell Biology

Key Properties

• CAS Number: 53308-83-1
• MW: 248.3
• Purity: > 98%
• Formula: C₇H₁₆N₄O₃ • CH₂COOH
• SMILES: CC(O)=O.CN=C(N)NCCCC(N)C(O)=O
• Target: NOS (Nitric oxide synthase)
• Solubility: Soluble in Water (up to 10 mg/ml).

Bioactivity

• Target IC50:
  iNOS:6 μM(Ki,mouse)|eNOS:0.4 μM(Ki,human)|nNOS:0.18 μM(Ki,rat)
• In Vitro:
  L-NMMA selectively inhibits vasodilator responses to endothelium-dependent ACh without affecting responses to endothelium-independent NP and does not alter isoprenaline-induced relaxation. Its inhibitory action remains unaffected by D-arginine but is countered by L-arginine (L-Arg). L-NMMA initiates a concentration-dependent decrease in vasodilation (2Hz) starting at 100 μM, achieving maximum inhibition around 35% at 1 mM. It reduces arteriolar diameter and increases arteriolar tone in a dose-dependent manner with an immediate onset of action. Moreover, L-NMMA significantly enhances NE-induced vasoconstriction.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NG-monomethyl-l-arginine

Compound Identifiers

PubChem CID

5702206