L-KAWAIN

SKU: orb1222162

Description

Kawain is one of the six major kavalactones found in the Piper methysticum (kava) plant; reversible inhibitor of MAO-B.(In Vitro):(+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF.

Key Properties

• CAS Number: 500-64-1
• MW: 230.26
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄O₃
• SMILES: COC1=CC(=O)O[C@H](C1)\C=C\c1ccccc1
• Target: BACE
• Solubility: DMSO : ≥ 125 mg/mL; 542.86 mM

Bioactivity

• In Vitro:
  (+)-Kavain (10-300 μM) enhances GABA-elicited responses in a concentration-dependent manner. The modulatory effect of Kavain is moderate, with only 170±23% of enhancement measured at 300 μM. (+)-Kavain inhibits TNF-α secretion in cells via suppression of LITAF.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

BACE