L-Hyoscyamine

SKU: orb1310126

Description

L-Hyoscyamine

Research Area

Neuroscience

Key Properties

• CAS Number: 101-31-5
• MW: 289.37
• Purity: 99.81%
• Formula: C₁₇H₂₃NO₃
• SMILES: CN1[C@H]2CC[C@@H]1CC(C2)OC(=O)[C@H](CO)c1ccccc1
• Target: AChR

Bioactivity

• Target IC50:
  AChR:7.5 nM
• In Vivo:
  In CHO cells, L-hyoscyamine inhibits excitant-induced cAMP production (EC50: 7.8 nM). In murine cardiac (atrial and ventricular) membranes, S-(-)-hyoscyamine enhances cyclic AMP synthesis stimulated by pilocarpine by 24%. R-(+)-hyoscyamine competes with [3H]NMS for binding to muscarinic acetylcholine receptor subtypes (m1-m5), with pKi values of 8.67, 8.51, 7.46, 8.56, and 8.53, respectively. L-hyoscyamine increases the TPase activity turnover rate from 0.19/min to 2.11/min in steady-state kinetic measurements.
• In Vitro:
  In vivo studies with conscious rats demonstrated that L-hyoscyamine (20 mg/kg) extended the cyclic period of migrating myoelectric complexes from 17.6 minutes to 29.0 minutes.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Daturine, alkaloid, AChR, Atropine, inhibit, Muscarinic acetylcholine receptor, muscarinic, Inhibitor, LHyoscyamine, L-Hyoscyamine, L Hyoscyamine, mAChR, Hyoscyamine, tropane

Compound Identifiers

PubChem CID

154417