L-Hyoscyamine

SKU: orb1310126

Description

L-Hyoscyamine (Daturine) is a belladonna alkaloid and competitive muscarinic receptor antagonist. It is used in research to study cholinergic pathways, employing in vitro receptor binding assays and in vivo models to investigate effects on smooth muscle contraction, glandular secretion, and gastrointestinal motility.

Research Area

Neuroscience

Key Properties

• CAS Number: 101-31-5
• MW: 289.37
• Purity: 99.81% (May vary between batches)
• Formula: C₁₇H₂₃NO₃
• SMILES: CN1[C@H]2CC[C@@H]1CC(C2)OC(=O)[C@H](CO)c1ccccc1
• Target: AChR
• Solubility: DMSO:55 mg/mL (190.07 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.91 mM);Ethanol:54 mg/mL (186.61 mM)

Bioactivity

• Target IC50:
  AChR:7.5 nM
• In Vivo:
  In CHO cells, L-hyoscyamine inhibits excitant-induced cAMP production (EC50: 7.8 nM). In murine cardiac (atrial and ventricular) membranes, S-(-)-hyoscyamine enhances cyclic AMP synthesis stimulated by pilocarpine by 24%. R-(+)-hyoscyamine competes with [3H]NMS for binding to muscarinic acetylcholine receptor subtypes (m1-m5), with pKi values of 8.67, 8.51, 7.46, 8.56, and 8.53, respectively. L-hyoscyamine increases the TPase activity turnover rate from 0.19/min to 2.11/min in steady-state kinetic measurements.
• In Vitro:
  In vivo studies with conscious rats demonstrated that L-hyoscyamine (20 mg/kg) extended the cyclic period of migrating myoelectric complexes from 17.6 minutes to 29.0 minutes.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Daturine, alkaloid, AChR, Atropine, inhibit, Muscarinic acetylcholine receptor, muscarinic, Inhibitor, LHyoscyamine, L-Hyoscyamine, L Hyoscyamine, mAChR, Hyoscyamine, tropane

Compound Identifiers

PubChem CID

154417