γ-L-Glutamyl-L-alanine

SKU: orb1220362

Description

γ-L-Glutamyl-L-alanine composed of gamma-glutamate and alanine is the substrate of CRF21 (gamma-Glutamylcyclotransferase GGCT).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 5875-41-2
• MW: 218.21
• Purity: >98% (HPLC)
• Formula: C₈H₁₄N₂O₅
• SMILES: CC(NC(=O)CCC(N)C(=O)O)C(=O)O
• Target: Others
• Solubility: H2O:50 mg/mL (229.14 mM)

Bioactivity

• In Vitro:
  γ-L-Glutamyl-L-alanine (γ-Glu-Ala) shows the potency for Ca2+i mobilization in CaR (calcium-sensing receptor)-expressing HEK-293 cells, with an EC50 of 4.8 μM. γ-L-Glutamyl-L-alanine shows the potency for Ca2+i mobilization in human parathyroid cells with an EC50 of 13.9 μM. γ-L-Glutamyl-L-alanine (20 μM) suppress PTH secretion from normal human parathyroid cells. γ-L-Glutamyl-L-alanine is a substrate for glutaminase B.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Others