L-Canavanine sulfate

SKU: orb1301444

Description

L-Canavanine sulfate

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2219-31-0
• MW: 274.25
• Purity: 99.96% (May vary between batches)
• Formula: C₅H₁₄N₄O₇S
• SMILES: OS(O)(=O)=O.N[C@@H](CCONC(N)=N)C(O)=O
• Target: NOD,NO Synthase
• Solubility: H2O:125 mg/mL (455.79 mM)

Bioactivity

• In Vivo:
  Intravenous infusion of L-canavanine (100 mg/kg), a selective inhibitor of inducible NO synthase in vitro, 60 min and 180 min after lipopolysaccharide challenge, produced an increase in mean arterial pressure and reversed the lipopolysaccharide induced hypotension. However, in lipopolysaccharide challenged animals protected from hypotension by administration of L-canavanine (60 min post challenge), intravenous infusion of NG-nitro-L-arginine methyl ester at 180 min post challenge caused an immediate rise in mean arterial pressure, followed by a rapid fall in blood pressure and heart rate, and sudden death. In contrast, a second dose of L-canavanine at 180 min post challenge maintained blood pressure for the duration of the experiment. Inhibition of both constitutive and inducible NO synthase during endotoxaemia is lethal.
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• In Vitro:
  L-Canavanine sulfate,which is hardly toxic alone, potentiated the cytotoxicity of VIN and PTX in HeLa and hepatocellular carcinoma cells.
• Cell Research:
  The following cancer cells grown in arginine-rich and arginine-free media were employed: HeLa, Hep G2 and SK-HEP-1. Drug combination experiment used a method based on the median-effect principle and mass-action law.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, NOS, NOSynthase, L Canavanine sulfate, Nitric oxide synthases, NO Synthase, NO synthesis, L-Canavanine, LCanavanine sulfate, L-Canavanine Sulfate

Compound Identifiers

PubChem CID

11957500