L-Buthionine-(S,R)-sulfoximine hydrochloride

• Catalog Number: orb1909016
• Category: Small Molecules
• Description: L-Buthionine-(S,R)-sulfoximine hydrochloride is a potent, cell-permeable, fast-acting, irreversible inhibitor of G-glutamylcysteine synthetase (γ-GCS) that depletes cellular glutathione levels. It has IC50s of 1.9 μM, 8.6 μM, and 29 μM in melanoma, breast, and ovarian tumor specimens, respectively [1] [2].
• Purity: 98.00%
• MW: 258.77
• Biological Activity: L-Buthionine-(S,R)-sulfoximine hydrochloride is a potent, cell-permeable, fast-acting and irreversible inhibitor of G-glutamylcysteine synthetase (γ-GCS) and depletes cellular glutathione levels. L-Buthionine-(S,R)-sulfoximine has IC50s of 1.9 μM, 8.6 μM, and 29 μM in melanoma, breast and ovarian tumor specimens, respectively [1] [2].
• Formula: C₈H₁₉ClN₂O₃S
• Storage: -20°C
• Note: For research use only