L-Asparaginase

SKU: orb1296743

Description

L-Asparaginase (L-ASNase) is a hydrolytic enzyme used as a chemotherapeutic agent, primarily for treating acute lymphoblastic leukemia (ALL). Its research applications extend to studying amino acid metabolism in cancer cell lines (in vitro) and evaluating therapeutic efficacy in animal models (in vivo) for various hematological malignancies.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 9015-68-3
• MW: 217.312
• Purity: 97.00% (May vary between batches)
• Formula: C₁₄H₁₉NO
• SMILES: CN(C)CC(=C)C(=O)c1ccc(C)cc1C
• Target: Apoptosis,DNA/RNA Synthesis
• Solubility: H2O:33 mg/mL

Bioactivity

• Target IC50:
  S180 cells:0.53 U/mL|C26 cells:0.17 U/mL|T-ALL cell:10^-2 and 10^-4 U/mL|4T1 cells:0.13 U/mL|HL-60 cells:0.31 U/mL

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA synthesis, DNA/RNA Synthesis, acute lymphoblastic leukemia, cancer, Apoptosis, L Asparaginase, L-​ASNase, L-?ASNase, inhibit, Inhibitor, L-ASNase, LAsparaginase, L-Asparaginase, L-asparagine, deamidating enzyme, RNA synthesis

Quick Database Links

Gene Symbol

Apoptosis,DNA/RNA Synthesis