L-Alanosine

SKU: orb1707110

Description

L-Alanosine is a Streptomyces-derived antibiotic that inhibits adenylosuccinate synthetase and methylthioadenosine phosphorylase, blocking de novo purine synthesis. This mechanism suppresses tumor cell proliferation, making it a valuable tool for cancer research in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology

Key Properties

• CAS Number: 5854-93-3
• MW: 149.11
• Formula: C₃H₇N₃O₄
• SMILES: C([C@@H](C(O)=O)N)N(N=O)O
• Target: Antibiotic,DNA/RNA Synthesis
• Solubility: H2O:10 mg/mL (67.06 mM)

Bioactivity

• In Vivo:
  Methods: L-Alanosine (150 mg/kg, i.p., three times per week) was administered to athymic nude mice transplanted with luciferase-expressing MTAP-deficient GBM cells that were injected with TMZ. In vivo drug responses were monitored by weekly bioluminescence imaging of the mice and analyzed using Living Image software. Results: Monotherapy with either TMZ or L-Alanosine alone was moderately effective in vivo, inhibiting tumor growth compared to vehicle-treated groups. Importantly, tumors in the combination treatment group remained stable after cessation of treatment compared to the monotherapy groups.
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• In Vitro:
  Methods: GBM cells were treated with L-Alanosine (0.25 μM and 0.5 μM for two weeks) to evaluate the effect of pre-exposure to ALA on OCR. Results: Pre-exposure to L-Alanosine resulted in a significant attenuation of maximal OCR (and abolished mitochondrial spare respiratory capacity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

LAlanosine, L-Alanosine, L Alanosine, NSC 153353, NSC153353, NSC-153353, SDX102, SDX-102

Compound Identifiers

PubChem CID

136096147