L-ABRINE b

SKU: orb1220711

Description

L-ABRINE is a toxic protein found in the jequirity seed.can be used as a biomarker for abrin exposure.

Key Properties

• CAS Number: 526-31-8
• MW: 218.25
• Purity: >98% (HPLC)
• Formula: C₁₂H₁₄N₂O₂
• SMILES: CN[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
• Target: Others
• Solubility: DMSO:2 mg/mL (9.16 mM)

Bioactivity

• In Vivo:
  Abrin is a toxic protein found in the jequirity seed. L-(+)-Abrine (L-Abrine) is also found in the jequirity seed and can be used as a biomarker for abrin exposure. An animal study is designed to monitor the excretion and recovery of L-(+)-Abrine in 20 rats. The animals are exposed to one of three concentrations of L-(+)-Abrine, a single high concentration of L-tryptophan, or no agent (control). The low L-(+)-Abrine dose corresponds to 0.63 LD50 i.p. abrin in mice, assuming a concentration ratio of 1: 4 of abrin to L-(+)-Abrine and an LD50 for abrin of 20 μg/kg. The mid and high L-(+)-Abrine (250 and 400 μg/kg) doses are included to ensure that the target analyte can be detected and tracked over the course of the experiment.
• In Vitro:
  L-(+)-Abrine is a marker for abrin poisoning. A strong indication for abrin poisoning is the presence of the chemical maker L-(+)-Abrine, which can survive metabolism in significant amounts making it detectable in human urine.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L-(+)-Abrine | L-N-Methyltryptophan | N-α-Methyl-L-tryptophan

Quick Database Links

Gene Symbol

Others