L-779450

SKU: orb1306989

Description

L-779450 is a potent and selective ATP-competitive inhibitor of Raf kinase with an IC50 of 10 nM. It exhibits strong selectivity, showing over 70-fold, 30-fold, and 7-fold preference for Raf over Lck, GSK3β, and p38α, respectively. This inhibitor is a valuable tool for investigating Raf-mediated signaling pathways in cancer research, both in cellular and biochemical assays.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 303727-31-3
• MW: 347.8
• Purity: 98.00% (May vary between batches)
• Formula: C₂₀H₁₄ClN₃O
• SMILES: Oc1cc(ccc1Cl)-c1[nH]c(nc1-c1ccncc1)-c1ccccc1
• Target: Raf,Autophagy
• Solubility: DMSO:60 mg/mL (172.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.75 mM)

Bioactivity

• Target IC50:
  Raf:10 nM|B-Raf:2.4 nM (Kd)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Autophagy, L779450, L-779450, Inhibitor, L 779450, inhibit, Raf, Raf kinases

Compound Identifiers

PubChem CID

9950176