L-778123 hydrochloride

SKU: orb1304451

Description

L-778123 hydrochloride is a dual inhibitor of farnesyltransferase (FPTase, IC50 = 2 nM) and geranylgeranyltransferase-I (GGPTase-I, IC50 = 98 nM). This compound has been utilized in vitro and in vivo to investigate the role of protein prenylation in Ras-related cancer pathways and signal transduction research.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 253863-00-2
• MW: 442.34
• Purity: 98.51% (May vary between batches)
• Formula: C₂₂H₂₁Cl₂N₅O
• SMILES: Cl.Clc1cccc(c1)N1CCN(Cc2cncn2Cc2ccc(cc2)C#N)CC1=O
• Target: Telomerase|||Transferase
• Solubility: PBS:100 mg/mL (226.07 mM);DMSO:200 mg/mL (452.14 mM)

Bioactivity

• Target IC50:
  GGTase I:98 nM|FPTase:2 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L 778123, Ftase, Farnesyl Transferase, FPTase, L-778,123, L778123, L-778123 Hydrochloride, L-778123

Compound Identifiers

PubChem CID

216453