L-694,247

SKU: orb1706004

Description

L-694,247 is a selective serotonin receptor agonist with high affinity for multiple 5-HT1 receptor subtypes. It serves as a valuable pharmacological tool for investigating the roles of these receptors in neurological disorders, applicable in both in vitro binding assays and in vivo animal models of migraine and anxiety.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 137403-12-4
• MW: 411.48
• Purity: 99.76% (May vary between batches)
• Formula: C₂₀H₂₁N₅O₃S
• SMILES: O=S(=O)(NC1=CC=C(C=C1)CC2=NOC(=N2)C3=CC=C4NC=C(C4=C3)CCN)C
• Target: 5-HT Receptor
• Solubility: DMSO:20 mg/mL (48.61 mM)

Bioactivity

• Target IC50:
  5-HTIB:9.1 (pIC50)|[125I]-GTI-5-HTID:10.0 (pIC50)
• In Vitro:
  L-694,247 displayed very high affinity (pIC50 = 10.0) for the 5-HTID site labelled with [125I]-GTI and was some 65-fold more potent in this regard than sumatriptan. It displayed somewhat lower affinity for the 5-HTIB binding site (pIC50 = 9.1) compared with the corresponding pIC50 value of 6.0 obtained with sumatriptan.

Storage & Handling

• Storage: keep away from moisture,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT, 5HTReceptor, 5HT Receptor, L 694,247, L694247, L694,247, L-694,247

Compound Identifiers

PubChem CID

132059