L-685,458

SKU: orb1222403

Description

L685458 is a potent and selective γ -secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. L685458 also exhibits equal potency for inhibition of A β 40 and A β 42 peptides (IC50 values are 48 and 67 nM respectively in human neuroblastoma cells). Also regulates CXCR4 and VEGFR2 expression through inhibition of Notch signaling in vitro.

Key Properties

• CAS Number: 292632-98-5
• MW: 672.85
• Purity: >98% (HPLC)
• Formula: C₃₉H₅₂N₄O₆
• SMILES: CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
• Target: γ secretase
• Solubility: DMSO : ≥ 31 mg/mL; 46.07 mM

Bioactivity

• In Vivo:
  Animal model: NOD-SCID Mouse Hepatoma Model. Dosage: 5 mg/kg. Administration: Percutaneous administration; 5 mg/kg; 2 weeks. Result: Exhibited anti-tumor activities In vivo.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

L685458 | L-685458 | L 685458

Quick Database Links

Gene Symbol

γ secretase