L-655708

SKU: orb2900174

Description

L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki=0.45 nM).

Key Properties

• CAS Number: 130477-52-0
• MW: 341.36
• Purity: >98% (HPLC)
• Formula: C₁₈H₁₉N₃O₄
• SMILES: [H][C@@]12CCCN1C(=O)c1cc(OC)ccc1-n1cnc(C(=O)OCC)c21
• Solubility: In Vitro: DMSO : 10 mg/mL (29.29 mM; Ultrasonic (<60°C)

Bioactivity

• In Vivo:
  L-655708 at 0.7 mg/kg, administered intraperitoneally, would result in 60-70% occupancy of α5 GABAA receptors with limited binding to α1, α2, and α3 subunit-containing GABAA receptors and no significant off-target behavioral effects, such as sedation and motor impairment.
• In Vitro:
  L655708 is a potent, selective inverse agonist for the benzodiazepine site of GABAA receptors containing the α5 subunit (Ki = 0.45 nM). Displays 50-100-fold selectivity over GABAA receptors containing α1, α2, α3 orα6 subunits in combination with β3 and γ2. Enhances LTP in a mouse hippocampal slice model and increases spatial learning, without displaying proconvulsant activity.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only