L-2-Hydroxyglutaric acid disodium

SKU: orb1308799

Description

L-2-Hydroxyglutaric acid disodium salt is an oncometabolite and epigenetic modifier implicated in renal cancer. It acts as a competitive inhibitor of mitochondrial creatine kinase (Mi-CK), with reported Km and Ki values of 2.52 mM and 11.13 mM, respectively. This compound is utilized in cancer metabolism research to study its roles in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Metabolism Research

Key Properties

• CAS Number: 63512-50-5
• MW: 192.08
• Purity: 99.92% (May vary between batches)
• Formula: C₅H₆Na₂O₅
• SMILES: [Na+].[Na+].O[C@@H](CCC([O-])=O)C([O-])=O
• Target: Histone Demethylase,Mitochondrial Metabolism,Endogenous Metabolite
• Solubility: H2O:100 mg/mL (520.62 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vitro:
  L-2-hydroxyglutarate can effectively inhibit 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs), including eleven eleven translocation (TET) enzymes .

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, L 2 Hydroxyglutaric acid disodium, methylation, modifier, MitochondrialMetabolism, Mitochondrial Metabolism, Inhibitor, L-2-Hydroxyglutaric acid, L2Hydroxyglutaric acid disodium, L-2-Hydroxyglutaric acid disodium, HistoneDemethylase, histone, Histone Demethylase, epigenetic, demethylases, (S)-2-Hydroxyglutaric acid disodium, 2-Hydroxyglutaric acid, 2-Hydroxyglutaric acid disodium, cancer, renal

Compound Identifiers

PubChem CID

56845267