KYP-2047

SKU: orb1298738

Description

KYP-2047 is a highly potent and selective inhibitor of Prolyl oligopeptidase (POP). This compound is a valuable research tool for investigating POP's role in neurological processes and is utilized in both in vitro biochemical assays and in vivo models of cognitive function.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 796874-99-2
• MW: 339.43
• Purity: 99.71% (May vary between batches)
• Formula: C₂₀H₂₅N₃O₂
• SMILES: C(=O)([C@H]1N(C(CCCC2=CC=CC=C2)=O)CCC1)N3[C@H](C#N)CCC3
• Target: Others,Prolyl Endopeptidase (PREP),MDM-2/p53,Apoptosis
• Solubility: DMSO:25 mg/mL (73.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.89 mM)

Bioactivity

• In Vitro:
  In cell lines, oxidative stress induced a robust aggregation of α-synuclein,and low concentrations of KYP-2047 significantly reduced the number of cells with α-synuclein inclusions while abolishing the colocalization of α-synuclein and PREP. KYP-2047 significantly reduced the amount of aggregated α-synuclein,and it had beneficial effects on cell viability. In the transgenic mice, a 5-day treatment with the PREP inhibitor reduced the amount of α-synuclein immunoreactivity and soluble α-synuclein protein in the brain.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Angiopoietins, Apoptosis, Inhibitor, MDM-2/p53, eNOS, Glioblastoma, KYP 2047, KYP2047, KYP-2047, inhibit, Neurotensin, VEGF, U-87 cell, POP, Prolyl oligopeptidase(pop), Prolyl Endopeptidase (PREP), prolyl oligopeptidase

Compound Identifiers

PubChem CID

11198569